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Oncology

Genetic testing for hereditary and somatic cancers can provide life-changing results in affected patients and their relatives, accompanied by potential actionable steps for genetic-related cancers. With many different applications of genetic testing to detect and care for cancer, we can guide you in selecting the right options to enhance the treatment of your patients suffering from hereditary cancers. Having identified genetic variants associated with oncological diseases in more than 200 different genes, we can provide a comprehensive range to foster cancer diagnosis, prognosis, treatment selection, and monitoring.


BRCA1, BRCA2 panel

Breast cancer is the most common type of cancer in woman constituting around 25% of all females cases. Mutations in BRCA1 and BRCA2 can increase the risk of developing cancer.

No. of genes:2
TAT:15 days
Coverage:≥99.5% ≥20x
Type:Germline
Details: Panel includes next-generation sequencing

Gene OMIM (Gene) Associated diseases (OMIM) Inheritance
BRCA1 113705 familial breast-ovarian cancer type 1; pancreatic cancer type 4; Fanconi anemia, complementation group S AD, AR
BRCA2 600185 familial breast-ovarian cancer type 2; Medulloblastoma; Prostate Cancer; Wilms tumor, type 1; Fanconi anemia complementation group D1; pancreatic cancer type 2 AD, AR

BRCA1, BRCA2 panel Combi (with MLPA)

No. of genes:2
TAT:15 days
Coverage:≥99.5% ≥20x
Type:Germline
Details:Panel includes next-generation sequencing and MLPA

Gene OMIM (Gene) Associated diseases (OMIM) Inheritance
BRCA1 113705 familial breast-ovarian cancer type 1; pancreatic cancer type 4; Fanconi anemia, complementation group S AD, AR
BRCA2 600185 familial breast-ovarian cancer type 2; Medulloblastoma; Prostate Cancer; Wilms tumor, type 1; Fanconi anemia complementation group D1; pancreatic cancer type 2 AD, AR

BRCA1, BRCA2 panel Plus

No. of genes:2
TAT:15 days
Coverage:≥99.5% ≥20x
Type:Germline
Details:Panel includes next-generation sequencing and CNV analysis

Gene OMIM (Gene) Associated diseases (OMIM) Inheritance
BRCA1 113705 familial breast-ovarian cancer type 1; pancreatic cancer type 4; Fanconi anemia, complementation group S AD, AR
BRCA2 600185 familial breast-ovarian cancer type 2; Medulloblastoma; Prostate Cancer; Wilms tumor, type 1; Fanconi anemia complementation group D1; pancreatic cancer type 2 AD, AR

BRCA1, BRCA2 somatic mutation analysis

No. of genes:2
TAT:10 days
Coverage:variable
Type:Somatic
Details:Panel includes next-generation sequencing

COMMON SYNDROMES AND DISORDERS COVERED

Breast cancer

Available Downloads for BRCA1, BRCA2 panels

  • Hereditary cancer panels - Product sheet

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CentoBreast®

CentoBreast® detects mutations in the BRCA1 and BRCA2 genes, which are the most common hereditary causes for breast cancer. In addition, our panel includes other genes such as ATM, BRIP1, CHEK2, PALB2, RAD51, etc. which have also been associated with increased cancer risk. Breast cancer is one of the most common cancers in the world affecting ~12.5% of women during their lifetime, with 5–10% of these patients having a hereditary form.

No. of genes:30
TAT:15 days
Coverage:≥99.5% ≥20x
Type:Germline
Details:CNV analysis included

Gene OMIM (Gene) Associated diseases (OMIM) Inheritance
ABRAXAS1 611143
ATM 607585 familial breast-ovarian cancer type 2; ataxia-telangiectasia AD, AR
BARD1 601593 familial breast-ovarian cancer type 2 AD
BRCA1 113705 familial breast-ovarian cancer type 1; pancreatic cancer type 4; Fanconi anemia, complementation group S AD, AR
BRCA2 600185 familial breast-ovarian cancer type 2; Medulloblastoma; Prostate Cancer; Wilms tumor, type 1; Fanconi anemia complementation group D1; pancreatic cancer type 2 AD, AR
BRIP1 605882 familial breast-ovarian cancer type 2; Fanconi anemia of complementation group J AD
CDH1 192090 familial breast-ovarian cancer type 2; blepharocheilodontic syndrome 1; Gastric Cancer, Hereditary Diffuse; Ovarian Cancer; Prostate Cancer; endometrial cancer AD
CHEK2 604373 familial breast-ovarian cancer type 2; Prostate Cancer; Osteogenic Sarcoma; Li-Fraumeni syndrome 2 AD
DICER1 606241 Goiter, multinodular 1, with or without Sertoli-Leydig cell tumors; Rhabdomyosarcoma, embryonal, 2; Pleuropulmonary blastoma AD
EPCAM 185535 Diarrhea 5, with tufting enteropathy, congenital; Colorectal cancer, hereditary nonpolyposis, type 8 AR
FANCC 613899 Fanconi anemia of complementation group C AR
MEN1 613733 multiple endocrine neoplasia type 1 AD
MLH1 120436 Muir-Torre syndrome; mismatch repair cancer syndrome; hereditary nonpolyposis colorectal cancer-2 AD, AR
MRE11 600814 Ataxia-telangiectasia-like disorder type 1 AR
MSH2 609309 Lynch syndrome; Muir-Torre syndrome; mismatch repair cancer syndrome AD, AR
MSH6 600678 mismatch repair cancer syndrome; endometrial cancer; hereditary nonpolyposis colorectal cancer-5 AD, AR
MUTYH 604933 familial adenomatous polyposis type 2; Gastric Cancer AR
NBN 602667 Nijmegen breakage syndrome; Aplastic Anemia; Acute lymphoblastic leukemia AR
PALB2 610355 familial breast-ovarian cancer type 2; Fanconi anemia of complementation group N; Pancreatic cancer, susceptibility to, 3 AD
PMS1 600258
PMS2 600259 mismatch repair cancer syndrome; hereditary nonpolyposis colorectal cancer-4 AR
PTEN 601728 Cowden syndrome 1; Cowden syndrome type 2; Bannayan-Riley-Ruvalcaba syndrome; Prostate Cancer; Macrocephaly/autism syndrome; Meningioma, familial, susceptibility to AD
RAD50 604040 Nijmegen breakage syndrome-like disorder
RAD51C 602774 Fanconi anemia of complementation group O; Breast-ovarian cancer, familial, susceptibility to, 3 AR
RAD51D 602954 susceptibility to familial breast-ovarian cancer type 4
RECQL 600537
SMARCA4 603254 Rhabdoid tumor predisposition syndrome 2; mental retardation-16 AD
STK11 602216 Peutz-Jeghers syndrome; Pancreatic Cancer; Spermatocytic seminoma, somatic AD
TP53 191170 familial breast-ovarian cancer type 2; colorectal cancer; Hepatocellular Carcinoma; Glioma susceptibility 1; Li-Fraumeni syndrome 1; Osteogenic Sarcoma; Pancreatic Cancer AD
XRCC2 600375 Fanconi anemia, complementation group U AR

COMMON SYNDROMES AND DISORDERS COVERED

Breast cancer
Ovarian cancer

Available Downloads for CentoBreast®

  • Hereditary cancer panels - Product sheet

    Download

CentoCancer®

Each gene in CentoCancer® has been carefully selected based on its risk potential in the development of one or more of the following cancers: breast, ovarian, colorectal, gastric, thyroid, endometrial, pancreatic, melanoma, renal, and prostate. This panel is appropiate for patients with positive personal history of early-onset cancer, rare cancer, bilateral cancer, or multiple primary cancers.

No. of genes:70
TAT:15 days
Coverage:≥99.5% ≥20x
Type:Germline
Details:CNV analysis included

Gene OMIM (Gene) Associated diseases (OMIM) Inheritance
ABRAXAS1 611143
APC 611731 colorectal cancer; Hepatocellular Carcinoma; Desmoid disease, hereditary; familial adenomatous polyposis; Gastric Cancer AD
ATM 607585 familial breast-ovarian cancer type 2; ataxia-telangiectasia AD, AR
AXIN2 604025 colorectal cancer; oligodontia-colorectal cancer syndrome AD
BAP1 603089 Tumor predisposition syndrome AD
BARD1 601593 familial breast-ovarian cancer type 2 AD
BLM 604610 Bloom syndrome AR
BMPR1A 601299 Juvenile polyposis syndrome, infantile form AD
BRCA1 113705 familial breast-ovarian cancer type 1; pancreatic cancer type 4; Fanconi anemia, complementation group S AD, AR
BRCA2 600185 familial breast-ovarian cancer type 2; Medulloblastoma; Prostate Cancer; Wilms tumor, type 1; Fanconi anemia complementation group D1; pancreatic cancer type 2 AD, AR
BRIP1 605882 familial breast-ovarian cancer type 2; Fanconi anemia of complementation group J AD
CDH1 192090 familial breast-ovarian cancer type 2; blepharocheilodontic syndrome 1; Gastric Cancer, Hereditary Diffuse; Ovarian Cancer; Prostate Cancer; endometrial cancer AD
CDK4 123829 Melanoma, Cutaneous Malignant, Susceptibility To, 3 AD
CDKN2A 600160 Malignant melanoma 2; Pancreatic cancer/melanoma syndrome AD
CHEK2 604373 familial breast-ovarian cancer type 2; Prostate Cancer; Osteogenic Sarcoma; Li-Fraumeni syndrome 2 AD
DICER1 606241 Goiter, multinodular 1, with or without Sertoli-Leydig cell tumors; Rhabdomyosarcoma, embryonal, 2; Pleuropulmonary blastoma AD
DIS3L2 614184 Perlman syndrome AR
EPCAM 185535 Diarrhea 5, with tufting enteropathy, congenital; Colorectal cancer, hereditary nonpolyposis, type 8 AR
FANCC 613899 Fanconi anemia of complementation group C AR
FH 136850 Leiomyomatosis and renal cell cancer; Fumarase deficiency AD, AR
FLCN 607273 colorectal cancer; Birt-Hogg-Dube syndrome; Renal carcinoma, chromophobe, somatic; primary spontaneous pneumothorax AD
GALNT12 610290 Colorectal cancer, susceptibility to, 1
HNF1B 189907 noninsulin-dependent diabetes mellitus / Diabetes mellitus type II; MODY type 5; Renal carcinoma, chromophobe, somatic AD
HOXB13 604607 Hereditary prostate cancer type 9
KIT 164920 Mast cell disease; Piebaldism; Spermatocytic seminoma, somatic; acute myeloid leukemia; gastrointestinal stromal tumor AD
MC1R 155555 oculocutaneous albinism type 2; skin/hair/eye pigmentation 2; Melanoma, cutaneous malignant, susceptibility to, 5 AR
MEN1 613733 multiple endocrine neoplasia type 1 AD
MET 164860 Hepatocellular Carcinoma; Renal cell carcinoma, papillary; deafness type 97 AD, AR
MITF 156845 Albinism, Ocular, With Sensorineural Deafness; Tietz Syndrome; Waardenburg syndrome type 2A; Melanoma, Cutaneous Malignant, Susceptibility To, 8 AD, AR
MLH1 120436 Muir-Torre syndrome; mismatch repair cancer syndrome; hereditary nonpolyposis colorectal cancer-2 AD, AR
MLH3 604395 colorectal cancer; endometrial cancer; Colorectal cancer, hereditary nonpolyposis, type 7 AD
MRE11 600814 Ataxia-telangiectasia-like disorder type 1 AR
MSH2 609309 Lynch syndrome; Muir-Torre syndrome; mismatch repair cancer syndrome AD, AR
MSH3 600887 endometrial cancer; Familial adenomatous polyposis 4 AR
MSH6 600678 mismatch repair cancer syndrome; endometrial cancer; hereditary nonpolyposis colorectal cancer-5 AD, AR
MUTYH 604933 familial adenomatous polyposis type 2; Gastric Cancer AR
NBN 602667 Nijmegen breakage syndrome; Aplastic Anemia; Acute lymphoblastic leukemia AR
NF1 613113 neurofibromatosis type 1; Neurofibromatosis-Noonan syndrome; Leukemia, juvenile myelomonocytic AD
NTHL1 602656 Familial adenomatous polyposis 3 AR
PALB2 610355 familial breast-ovarian cancer type 2; Fanconi anemia of complementation group N; Pancreatic cancer, susceptibility to, 3 AD
PMS1 600258
PMS2 600259 mismatch repair cancer syndrome; hereditary nonpolyposis colorectal cancer-4 AR
POLD1 174761 Colorectal cancer, susceptibility to type 10; MANDIBULAR HYPOPLASIA, DEAFNESS, PROGEROID FEATURES, AND LIPODYSTROPHY SYNDROME AD
POLE 174762 Colorectal cancer, susceptibility to, 12; FILS syndrome AD, AR
POT1 606478 Melanoma, cutaneous malignant, susceptibility to, 10 AD
PRSS1 276000 hereditary pancreatitis AD
PTCH1 601309 Gorlin syndrome; Holoprosencephaly-7 AD
PTEN 601728 Cowden syndrome 1; Cowden syndrome type 2; Bannayan-Riley-Ruvalcaba syndrome; Prostate Cancer; Macrocephaly/autism syndrome; Meningioma, familial, susceptibility to AD
RAD50 604040 Nijmegen breakage syndrome-like disorder
RAD51C 602774 Fanconi anemia of complementation group O; Breast-ovarian cancer, familial, susceptibility to, 3 AR
RAD51D 602954 susceptibility to familial breast-ovarian cancer type 4
RECQL 600537
RET 164761 Hirschsprung disease; familial medullary thyroid carcinoma; multiple endocrine neoplasia 2B; pheochromocytoma; multiple endocrine neoplasia 2A; congenital central hypoventilation syndrome AD
RNF43 612482 AD
SDHA 600857 mitochondrial complex II deficiency; Leigh syndrome; dilated cardiomyopathy-1GG; paragangliomas type 5 AD, AR, M
SDHAF2 613019 paragangliomas type 2 AD
SDHB 185470 paragangliomas type 4; pheochromocytoma; gastrointestinal stromal tumor; paraganglioma and gastric stromal sarcoma AD
SDHC 602413 Paragangliomas 3; gastrointestinal stromal tumor; paraganglioma and gastric stromal sarcoma AD
SDHD 602690 paragangliomas 1; pheochromocytoma; mitochondrial complex II deficiency; paraganglioma and gastric stromal sarcoma AD, AR
SMAD4 600993 Myhre syndrome; Juvenile polyposis syndrome, infantile form; Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome; Pancreatic Cancer AD
SMARCA4 603254 Rhabdoid tumor predisposition syndrome 2; mental retardation-16 AD
STK11 602216 Peutz-Jeghers syndrome; Pancreatic Cancer; Spermatocytic seminoma, somatic AD
TGFBR2 190182 Esophageal cancer, somatic; Loeys-Dietz syndrome 2; Colorectal cancer, hereditary nonpolyposis, type 6 AD
TP53 191170 familial breast-ovarian cancer type 2; colorectal cancer; Hepatocellular Carcinoma; Glioma susceptibility 1; Li-Fraumeni syndrome 1; Osteogenic Sarcoma; Pancreatic Cancer AD
TSC1 605284 tuberous sclerosis type 1 AD
TSC2 191092 tuberous sclerosis-2 AD
VHL 608537 Renal carcinoma, chromophobe, somatic; pheochromocytoma; von Hippel-Lindau disease; Erythrocytosis, familial, 2 AD, AR
WT1 607102 Frasier syndrome; Mesothelioma, somatic; Wilms tumor, type 1; Denys-Drash syndrome; Nephrotic syndrome, type 4; Meacham syndrome AD
XRCC2 600375 Fanconi anemia, complementation group U AR
XRCC3 600675 familial breast-ovarian cancer type 2 AD

COMMON SYNDROMES AND DISORDERS COVERED

Breast cancer
Colorectal cancer
Endometrial cancer
Familial adenomatous polyposis
Gastric cancer
Gastrointestinal stromal tumor
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Thyroid cancer
Uterine cancer

Available Downloads for CentoCancer®

  • Hereditary cancer panels - Product sheet

    Download

CentoCancer® comprehensive

CentoCancer® comprehensive is our most extensive cancer panel, covering a large number of cancer-associated genes. Each gene in this panel has been carefully selected based on its risk potential in the development of one or more of the following cancers: breast, ovarian, colorectal, gastric, thyroid, endometrial, pancreatic, melanoma, renal, and prostate, among others.

No. of genes:110
TAT:15 days
Coverage:~99% ≥20x
Type:Germline
Details:CNV analysis included

Gene OMIM (Gene) Associated diseases (OMIM) Inheritance
ABRAXAS1 611143
ACVRL1 601284 Telangiectasia, hereditary hemorrhagic, type 2 AD
AKT1 164730 familial breast-ovarian cancer type 2; colorectal cancer; Ovarian Cancer; Proteus Syndrome; Cowden syndrome 6
APC 611731 colorectal cancer; Hepatocellular Carcinoma; Desmoid disease, hereditary; familial adenomatous polyposis; Gastric Cancer AD
ATM 607585 familial breast-ovarian cancer type 2; ataxia-telangiectasia AD, AR
AXIN2 604025 colorectal cancer; oligodontia-colorectal cancer syndrome AD
BAP1 603089 Tumor predisposition syndrome AD
BARD1 601593 familial breast-ovarian cancer type 2 AD
BLM 604610 Bloom syndrome AR
BMPR1A 601299 Juvenile polyposis syndrome, infantile form AD
BRCA1 113705 familial breast-ovarian cancer type 1; pancreatic cancer type 4; Fanconi anemia, complementation group S AD, AR
BRCA2 600185 familial breast-ovarian cancer type 2; Medulloblastoma; Prostate Cancer; Wilms tumor, type 1; Fanconi anemia complementation group D1; pancreatic cancer type 2 AD, AR
BRIP1 605882 familial breast-ovarian cancer type 2; Fanconi anemia of complementation group J AD
BUB1B 602860 colorectal cancer; mosaic variegated aneuploidy syndrome 1 AD, AR
CASR 601199 Hypocalciuric hypercalcemia, type I; Hyperparathyroidism, neonatal; Hypocalcemia, autosomal dominant, with Bartter syndrome; Epilepsy idiopathic generalized, susceptibility to, 8 AD, AR
CDC73 607393 Hyperparathyroidism-jaw tumor syndrome AD
CDH1 192090 familial breast-ovarian cancer type 2; blepharocheilodontic syndrome 1; Gastric Cancer, Hereditary Diffuse; Ovarian Cancer; Prostate Cancer; endometrial cancer AD
CDK4 123829 Melanoma, Cutaneous Malignant, Susceptibility To, 3 AD
CDKN1B 600778 Multiple endocrine neoplasia, type IV AD
CDKN1C 600856 Beckwith-Wiedemann syndrome; IMAGE syndrome AD
CDKN2A 600160 Malignant melanoma 2; Pancreatic cancer/melanoma syndrome AD
CEBPA 116897 acute myeloid leukemia AD
CHEK2 604373 familial breast-ovarian cancer type 2; Prostate Cancer; Osteogenic Sarcoma; Li-Fraumeni syndrome 2 AD
CTNNA1 116805 AD
DDX41 608170 Susceptibility to multiple types of familial myeloproliferative/lymphoproliferative neoplasms AD
DICER1 606241 Goiter, multinodular 1, with or without Sertoli-Leydig cell tumors; Rhabdomyosarcoma, embryonal, 2; Pleuropulmonary blastoma AD
DIS3L2 614184 Perlman syndrome AR
EGFR 131550 Lung Cancer AD, AR
EPCAM 185535 Diarrhea 5, with tufting enteropathy, congenital; Colorectal cancer, hereditary nonpolyposis, type 8 AR
ETV6 600618 acute myeloid leukemia; Thrombocytopenia 5 AD
EXT1 608177 multiple exostoses type 1 AD
EXT2 608210 Exostoses, multiple, type 2; Seizures, scoliosis, and macrocephaly syndrome AD, AR
FANCC 613899 Fanconi anemia of complementation group C AR
FH 136850 Leiomyomatosis and renal cell cancer; Fumarase deficiency AD, AR
FLCN 607273 colorectal cancer; Birt-Hogg-Dube syndrome; Renal carcinoma, chromophobe, somatic; primary spontaneous pneumothorax AD
GALNT12 610290 Colorectal cancer, susceptibility to, 1
GATA2 137295 acute myeloid leukemia; Lymphedema, primary, with myelodysplasia; Immunodeficiency 21; Myelodysplastic syndrome, somatic AD
GPC3 300037 Wilms tumor, type 1; Simpson-Golabi-Behmel syndrome, type 1 XLR
GREM1 603054
HNF1A 142410 noninsulin-dependent diabetes mellitus / Diabetes mellitus type II; Renal carcinoma, chromophobe, somatic; Diabetes mellitus, insulin-dependent-1; MODY type 3 AD, AR
HNF1B 189907 noninsulin-dependent diabetes mellitus / Diabetes mellitus type II; MODY type 5; Renal carcinoma, chromophobe, somatic AD
HOXB13 604607 Hereditary prostate cancer type 9
HRAS 190020 Bladder Cancer; Melanocytic nevus syndrome, congenital, somatic; Nevus, Epidermal; Schimmelpenning-Feuerstein-Mims Syndrome; Thyroid Carcinoma, Follicular; Costello syndrome AD
KIF1B 605995 type 2A1 Charcot-Marie-Tooth disease; pheochromocytoma AD
KIT 164920 Mast cell disease; Piebaldism; Spermatocytic seminoma, somatic; acute myeloid leukemia; gastrointestinal stromal tumor AD
MAX 154950 pheochromocytoma AD
MC1R 155555 oculocutaneous albinism type 2; skin/hair/eye pigmentation 2; Melanoma, cutaneous malignant, susceptibility to, 5 AR
MEN1 613733 multiple endocrine neoplasia type 1 AD
MET 164860 Hepatocellular Carcinoma; Renal cell carcinoma, papillary; deafness type 97 AD, AR
MITF 156845 Albinism, Ocular, With Sensorineural Deafness; Tietz Syndrome; Waardenburg syndrome type 2A; Melanoma, Cutaneous Malignant, Susceptibility To, 8 AD, AR
MLH1 120436 Muir-Torre syndrome; mismatch repair cancer syndrome; hereditary nonpolyposis colorectal cancer-2 AD, AR
MLH3 604395 colorectal cancer; endometrial cancer; Colorectal cancer, hereditary nonpolyposis, type 7 AD
MRE11 600814 Ataxia-telangiectasia-like disorder type 1 AR
MSH2 609309 Lynch syndrome; Muir-Torre syndrome; mismatch repair cancer syndrome AD, AR
MSH3 600887 endometrial cancer; Familial adenomatous polyposis 4 AR
MSH6 600678 mismatch repair cancer syndrome; endometrial cancer; hereditary nonpolyposis colorectal cancer-5 AD, AR
MUTYH 604933 familial adenomatous polyposis type 2; Gastric Cancer AR
NBN 602667 Nijmegen breakage syndrome; Aplastic Anemia; Acute lymphoblastic leukemia AR
NF1 613113 neurofibromatosis type 1; Neurofibromatosis-Noonan syndrome; Leukemia, juvenile myelomonocytic AD
NF2 607379 neurofibromatosis type 2; Schwannomatosis; Meningioma, familial, susceptibility to AD
NTHL1 602656 Familial adenomatous polyposis 3 AR
PALB2 610355 familial breast-ovarian cancer type 2; Fanconi anemia of complementation group N; Pancreatic cancer, susceptibility to, 3 AD
PDGFRA 173490 Hypereosinophilic Syndrome, Idiopathic
PHOX2B 603851 congenital central hypoventilation syndrome AD
PIK3CA 171834 familial breast-ovarian cancer type 2; colorectal cancer; Hepatocellular Carcinoma; Nevus, Epidermal; Ovarian Cancer; Keratosis, Seborrheic; Lung Cancer; Megalencephaly-Capillary Malformation-Polymicrogyria Syndrome; Congenital Lipomatous Overgrowth, Vascular Malformations, And Epidermal Nevi; Gastric Cancer; Cowden syndrome 5
PMS1 600258
PMS2 600259 mismatch repair cancer syndrome; hereditary nonpolyposis colorectal cancer-4 AR
POLD1 174761 Colorectal cancer, susceptibility to type 10; MANDIBULAR HYPOPLASIA, DEAFNESS, PROGEROID FEATURES, AND LIPODYSTROPHY SYNDROME AD
POLE 174762 Colorectal cancer, susceptibility to, 12; FILS syndrome AD, AR
POT1 606478 Melanoma, cutaneous malignant, susceptibility to, 10 AD
PRKAR1A 188830 Acrodysostosis 1 With Or Without Hormone Resistance; Carney complex, type 1; Myxoma, intracardiac; Pigmented nodular adrenocortical disease, primary, 1 AD
PRSS1 276000 hereditary pancreatitis AD
PTCH1 601309 Gorlin syndrome; Holoprosencephaly-7 AD
PTCH2 603673 Gorlin syndrome; Medulloblastoma AD
PTEN 601728 Cowden syndrome 1; Cowden syndrome type 2; Bannayan-Riley-Ruvalcaba syndrome; Prostate Cancer; Macrocephaly/autism syndrome; Meningioma, familial, susceptibility to AD
RAD50 604040 Nijmegen breakage syndrome-like disorder
RAD51C 602774 Fanconi anemia of complementation group O; Breast-ovarian cancer, familial, susceptibility to, 3 AR
RAD51D 602954 susceptibility to familial breast-ovarian cancer type 4
RB1 614041 Bladder Cancer; retinoblastoma; Osteogenic Sarcoma AD
RECQL 600537
REST 600571 AD
RET 164761 Hirschsprung disease; familial medullary thyroid carcinoma; multiple endocrine neoplasia 2B; pheochromocytoma; multiple endocrine neoplasia 2A; congenital central hypoventilation syndrome AD
RNF43 612482 AD
RPS20 603682
RUNX1 151385 Platelet disorder, familial, with associated myeloid malignancy; acute myeloid leukemia AD
SAMD9L 611170 Ataxia-pancytopenia syndrome AD
SDHA 600857 mitochondrial complex II deficiency; Leigh syndrome; dilated cardiomyopathy-1GG; paragangliomas type 5 AD, AR, M
SDHAF2 613019 paragangliomas type 2 AD
SDHB 185470 paragangliomas type 4; pheochromocytoma; gastrointestinal stromal tumor; paraganglioma and gastric stromal sarcoma AD
SDHC 602413 Paragangliomas 3; gastrointestinal stromal tumor; paraganglioma and gastric stromal sarcoma AD
SDHD 602690 paragangliomas 1; pheochromocytoma; mitochondrial complex II deficiency; paraganglioma and gastric stromal sarcoma AD, AR
SMAD4 600993 Myhre syndrome; Juvenile polyposis syndrome, infantile form; Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome; Pancreatic Cancer AD
SMARCA2 600014 Nicolaides-Baraitser syndrome AD
SMARCA4 603254 Rhabdoid tumor predisposition syndrome 2; mental retardation-16 AD
SMARCB1 601607 Schwannomatosis; Rhabdoid tumors, somatic; Coffin-Siris syndrome 3 AD
SMARCE1 603111 Meningioma, familial, susceptibility to AD
STK11 602216 Peutz-Jeghers syndrome; Pancreatic Cancer; Spermatocytic seminoma, somatic AD
SUFU 607035 Gorlin syndrome; Medulloblastoma; Meningioma, familial, susceptibility to AD, AR
TERT 187270 acute myeloid leukemia; Dyskeratosis congenita 4; Bone marrow failure, telomere-related, 1 AD, AR
TGFBR2 190182 Esophageal cancer, somatic; Loeys-Dietz syndrome 2; Colorectal cancer, hereditary nonpolyposis, type 6 AD
TMEM127 613403 pheochromocytoma AD
TP53 191170 familial breast-ovarian cancer type 2; colorectal cancer; Hepatocellular Carcinoma; Glioma susceptibility 1; Li-Fraumeni syndrome 1; Osteogenic Sarcoma; Pancreatic Cancer AD
TRIP13 604507 AR
TSC1 605284 tuberous sclerosis type 1 AD
TSC2 191092 tuberous sclerosis-2 AD
VHL 608537 Renal carcinoma, chromophobe, somatic; pheochromocytoma; von Hippel-Lindau disease; Erythrocytosis, familial, 2 AD, AR
WRN 604611 Werner syndrome AR
WT1 607102 Frasier syndrome; Mesothelioma, somatic; Wilms tumor, type 1; Denys-Drash syndrome; Nephrotic syndrome, type 4; Meacham syndrome AD
XRCC2 600375 Fanconi anemia, complementation group U AR
XRCC3 600675 familial breast-ovarian cancer type 2 AD

COMMON SYNDROMES AND DISORDERS COVERED

Beckwith-Wiedemann syndrome
Breast cancer
Colorectal cancer
Endometrial cancer
Familial adenomatous polyposis
Gastric cancer
Gastrointestinal stromal tumor
Hereditary Paraganglioma/ Pheochromocytoma
Melanoma
Ovarian cancer
Pancreatic cancer
Paragangliomas/Pheochromocytoma/
Gastrointestinal stromal
Prostate cancer
Renal cancer
Retinoblastoma
Rothmund-Thomson syndrome (Type 2)
Skin cancer
Thyroid cancer
Uterine cancer

Available Downloads for CentoCancer® comprehensive

  • Hereditary cancer panels - Product sheet

    Download

CentoColon

CentoColon detects genes that are associated with colon, pancreatic, and gastric cancer.

No. of genes:33
TAT:15 days
Coverage:≥99.5% ≥20x
Type:Germline
Details:CNV analysis included

Gene OMIM (Gene) Associated diseases (OMIM) Inheritance
APC 611731 colorectal cancer; Hepatocellular Carcinoma; Desmoid disease, hereditary; familial adenomatous polyposis; Gastric Cancer AD
ATM 607585 familial breast-ovarian cancer type 2; ataxia-telangiectasia AD, AR
AXIN2 604025 colorectal cancer; oligodontia-colorectal cancer syndrome AD
BLM 604610 Bloom syndrome AR
BMPR1A 601299 Juvenile polyposis syndrome, infantile form AD
BRCA1 113705 familial breast-ovarian cancer type 1; pancreatic cancer type 4; Fanconi anemia, complementation group S AD, AR
BRCA2 600185 familial breast-ovarian cancer type 2; Medulloblastoma; Prostate Cancer; Wilms tumor, type 1; Fanconi anemia complementation group D1; pancreatic cancer type 2 AD, AR
CDH1 192090 familial breast-ovarian cancer type 2; blepharocheilodontic syndrome 1; Gastric Cancer, Hereditary Diffuse; Ovarian Cancer; Prostate Cancer; endometrial cancer AD
CDKN2A 600160 Malignant melanoma 2; Pancreatic cancer/melanoma syndrome AD
CHEK2 604373 familial breast-ovarian cancer type 2; Prostate Cancer; Osteogenic Sarcoma; Li-Fraumeni syndrome 2 AD
EPCAM 185535 Diarrhea 5, with tufting enteropathy, congenital; Colorectal cancer, hereditary nonpolyposis, type 8 AR
FLCN 607273 colorectal cancer; Birt-Hogg-Dube syndrome; Renal carcinoma, chromophobe, somatic; primary spontaneous pneumothorax AD
GALNT12 610290 Colorectal cancer, susceptibility to, 1
MLH1 120436 Muir-Torre syndrome; mismatch repair cancer syndrome; hereditary nonpolyposis colorectal cancer-2 AD, AR
MLH3 604395 colorectal cancer; endometrial cancer; Colorectal cancer, hereditary nonpolyposis, type 7 AD
MSH2 609309 Lynch syndrome; Muir-Torre syndrome; mismatch repair cancer syndrome AD, AR
MSH3 600887 endometrial cancer; Familial adenomatous polyposis 4 AR
MSH6 600678 mismatch repair cancer syndrome; endometrial cancer; hereditary nonpolyposis colorectal cancer-5 AD, AR
MUTYH 604933 familial adenomatous polyposis type 2; Gastric Cancer AR
NBN 602667 Nijmegen breakage syndrome; Aplastic Anemia; Acute lymphoblastic leukemia AR
NTHL1 602656 Familial adenomatous polyposis 3 AR
PALB2 610355 familial breast-ovarian cancer type 2; Fanconi anemia of complementation group N; Pancreatic cancer, susceptibility to, 3 AD
PMS2 600259 mismatch repair cancer syndrome; hereditary nonpolyposis colorectal cancer-4 AR
POLD1 174761 Colorectal cancer, susceptibility to type 10; MANDIBULAR HYPOPLASIA, DEAFNESS, PROGEROID FEATURES, AND LIPODYSTROPHY SYNDROME AD
POLE 174762 Colorectal cancer, susceptibility to, 12; FILS syndrome AD, AR
PRSS1 276000 hereditary pancreatitis AD
PTEN 601728 Cowden syndrome 1; Cowden syndrome type 2; Bannayan-Riley-Ruvalcaba syndrome; Prostate Cancer; Macrocephaly/autism syndrome; Meningioma, familial, susceptibility to AD
RNF43 612482 AD
SMAD4 600993 Myhre syndrome; Juvenile polyposis syndrome, infantile form; Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome; Pancreatic Cancer AD
STK11 602216 Peutz-Jeghers syndrome; Pancreatic Cancer; Spermatocytic seminoma, somatic AD
TGFBR2 190182 Esophageal cancer, somatic; Loeys-Dietz syndrome 2; Colorectal cancer, hereditary nonpolyposis, type 6 AD
TP53 191170 familial breast-ovarian cancer type 2; colorectal cancer; Hepatocellular Carcinoma; Glioma susceptibility 1; Li-Fraumeni syndrome 1; Osteogenic Sarcoma; Pancreatic Cancer AD
VHL 608537 Renal carcinoma, chromophobe, somatic; pheochromocytoma; von Hippel-Lindau disease; Erythrocytosis, familial, 2 AD, AR

COMMON SYNDROMES AND DISORDERS COVERED

Colorectal cancer
Familial adenomatous polyposis
Gastric cancer
Hereditary nonpolyposis colorectal cancer
Pancreatic cancer

Available Downloads for CentoColon

  • Hereditary cancer panels - Product sheet

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Myeloid tumor panel

Our myeloid tumor panel targets important regions within 35 genes that are frequently mutated in myeloid malignancies. Myeloid malignancies are clonal diseases of hematopoietic progenitor cells. Myeloid tumors represent the fourth most frequently diagnosed cancer in economically developed countries. The majority of myeloid tumors contain high numbers of somatic mutations, which are genetic changes that are not inherited but created within the tumor itself. Unlike inherited “germline” mutations, these somatic mutations are not transmitted to offspring. Somatic mutations significantly contribute to the pathogenesis, progression, and prognosis of myeloid malignancies.

No. of genes:35
TAT:10 days
Coverage:>97% >200x
Type:Somatic

COMMON SYNDROMES AND DISORDERS COVERED

Acute myeloid leukemia
Chronic myeloid leukemia
Chronic myelomonocytic leukemia
Juvenile myelomonocytic leukemia
Myelodysplastic syndrome
Myeloid tumor
Myeloproliferative neoplasms

DOWNLOADS AVAILABLE FOR Myeloid tumor panel

Solid tumor panel

Our solid tumor panel provides full sequencing of 106 selected cancer-associated genes as well as the hotspot analysis of relevant cancer regions in 43 genes. It detects over 5,000 validated oncogenic variants and includes the latest evidence-based variants associated with treatment decisions in solid tumors. The panel has more than 25 genes with approved targeted therapies or those that are being currently tested in clinical trials. Furthermore, somatic variants with an impact on prognosis of the individual tumor or on the efficacy of standard anti-tumor therapy are captured. It covers more than 100 different types of somatic cancers, including adrenal, colon, hepatic, prostate, renal, skin, testicular, thyroid, glioma, esophageal, endometrial, and breast cancer, among others. The panel provides a better understanding of tumor behavior as well as its likelihood to respond to a treatment, contributing to tailored medicine for the patient, thus frequently leading to a better outcome or reduced adverse effects.

No. of genes:149
TAT:10 days
Coverage:>97% >200x
Type:Somatic

COMMON SYNDROMES AND DISORDERS COVERED

Adrenal cancer
Biliary tract cancer
Bone marrow cancer
Breast cancer
Colon cancer
Endometrial cancer
Esophageal cancer
Gastrointestinal stromal tumor
Glioma
Hepatic cancer
Lung cancer
Lymphoma cancer
Meningioma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Testicular cancer
Thyroid cancer

Downloads available for Solid Tumor Panel

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