Understanding Neurodegeneration in Niemann-Pick Disease

Alteration of GABAergic input precedes neurodegeneration of cerebellar Purkinje cells of NPC1-deficient mice

Niemann-Pick (NP) disease is a lysosomal storage disorder that involves the degeneration of certain neurons. A recent study, co-authored by CENTOGENE’s CEO Prof. Arndt Rolfs, investigated this process using an electrophysiological approach. The findings of disturbed synaptic signaling open up novel therapeutic options; they were published in the International Journal of Molecular Sciences.

Authors

  • Michael Rabenstein
  • Nico Murr
  • Andreas Hermann , MD
  • Prof. Arndt Rolfs , MD
  • Moritz J Frech , PhD

Topics

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